Application
There have been several experiments which have studied these interactions further and revealed AVPR1B’s role in psychological disorders and regulatory functions. Halotypes of AVPR1B are associated with increased protective effects to recurrent major depression. AVPR1B has also been associated with higher cortisol responses to psychosocial stress in children with psychiatric disorders compared with carriers of glucocorticoid receptor gene. AVPR1b has also shown involvement in regulation of brain water content and cerebral Edama. This was revealed as increased levels of AVPR1B mRNA on the choroid plexus were discovered as a result of increased plasma osmolality. The increase after a reduction of brain water content from salt water loading indicated AVBR1B’s role in the neuroendocrine feedback loop in maintaining normal central nervous system fluid balance.
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