Arginine Vasopressin Receptor 1B
Vasopressin V1b receptor (V1bR) also known as vasopressin 3 receptor (VPR3) or antidiuretic hormone receptor 1b is a protein that in humans is encoded by the AVPR1B (arginine vasopressin receptor 1B) gene.
V1bR acts as receptor for arginine vasopressin. AVPR1B belongs to the subfamily of G-protein coupled receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system.It is a major contributor to homeostasis and the control of water, glucose, and salts in the blood. Arginine vasopressin has four receptors, each of which are located in different tissues and have specific functions. AVPR1b is a g-protein coupled pituitary receptor that has only recently been characterized because of its rarity.
It has been found that the 420-amino-acid sequence of the AVPR1B receptor shared the most overall similarities with the AVP1A, AVP2 and oxytocin receptors. AVPR1B maps to chromosome region 1q32 and is a member of the vasopressin/oxytocin family subfamily.
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