Anti-transglutaminase Antibodies - Transglutaminase Isoform Reactivity - Anti-tissue Transglutaminase

Anti-tissue Transglutaminase

Antibodies to tissue transglutaminase (ATA or anti-tTG) are found in patients with several conditions, including coeliac disease, juvenile diabetes, inflammatory bowel disease, and various forms of arthritis.

In Coeliac Disease, ATA are involved in the destruction of the villous extracellular matrix and target the destruction of intestinal villous epithelial cells by killer cells. Deposits of anti-tTG in the intestinal epithelium predict coeliac disease.

Read more about this topic:  Anti-transglutaminase Antibodies, Transglutaminase Isoform Reactivity