Anti-transglutaminase Antibodies

Anti-transglutaminase antibodies (ATA) are autoantibodies against the transglutaminase protein. Antibodies serve an important role in the immune system by detecting cells and substances that the rest of the immune system then eliminates. These cells and substance can be foreign (for example, viruses) and also can be produced by the body (for example, cancer cells). Antibodies against the body's own products are called autoantibodies. Autoantibodies can sometimes errantly be directed against healthy portions of the organism, causing autoimmune diseases.

ATA can be classified according to 2 different schemes: transglutaminase isoform and immunoglobulin reactivity subclass (IgA, IgG) toward transglutaminases.

Read more about Anti-transglutaminase AntibodiesImmunoglobin Subclass, Mechanism of Autoimmunity

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Anti-transglutaminase Antibodies - Mechanism of Autoimmunity
... The antibodies to tissue transglutaminase follow a complex pathway of generation ... Some studies have revealed that antibodies increase the activity of tTG, instead of inhibiting activity as is commonly encountered with function alterning antibodies ...