Problems and Errors
aDNA may contain a large number of postmortem mutations, increasing with time. Some regions of polynucleotide are more susceptible to this degradation so sequence data can bypass statistical filters used to check the validity of data. Due to sequencing errors, great caution should be applied to interpretation of population size. Substitutions resulting from deamination cytosine residues are vastly overrepresented in the ancient DNA sequences. Miscoding of C to T and G to A accounts for the majority of errors.
Read more about this topic: Ancient DNA
Famous quotes containing the words problems and/or errors:
“Our young people are diseased with the theological problems of original sin, origin of evil, predestination, and the like. These never presented a practical difficulty to any man,—never darkened across any man’s road, who did not go out of his way to seek them. These are the soul’s mumps, and measles, and whooping- coughs, and those who have not caught them cannot describe their health or prescribe a cure. A simple mind will not know these enemies.”
—Ralph Waldo Emerson (1803–1882)
“Science in the modern world has many uses; its chief use, however, is to provide long words to cover the errors of the rich.”
—Gilbert Keith Chesterton (1874–1936)