Problems and Errors
aDNA may contain a large number of postmortem mutations, increasing with time. Some regions of polynucleotide are more susceptible to this degradation so sequence data can bypass statistical filters used to check the validity of data. Due to sequencing errors, great caution should be applied to interpretation of population size. Substitutions resulting from deamination cytosine residues are vastly overrepresented in the ancient DNA sequences. Miscoding of C to T and G to A accounts for the majority of errors.
Read more about this topic: Ancient DNA
Famous quotes containing the words problems and, problems and/or errors:
“I believe that if we are to survive as a planet, we must teach this next generation to handle their own conflicts assertively and nonviolently. If in their early years our children learn to listen to all sides of the story, use their heads and then their mouths, and come up with a plan and share, then, when they become our leaders, and some of them will, they will have the tools to handle global problems and conflict.”
—Barbara Coloroso (20th century)
“If we parents accept that problems are an essential part of life’s challenges, rather than reacting to every problem as if something has gone wrong with universe that’s supposed to be perfect, we can demonstrate serenity and confidence in problem solving for our kids....By telling them that we know they have a problem and we know they can solve it, we can pass on a realistic attitude as well as empower our children with self-confidence and a sense of their own worth.”
—Barbara Coloroso (20th century)
“Let us pardon him his hope of a vain apocalypse, and of a second coming in great triumph upon the clouds of heaven. Perhaps these were the errors of others rather than his own; and if it be true that he himself shared the general illusion, what matters it, since his dream rendered him strong against death, and sustained him in a struggle to which he might otherwise have been unequal?”
—Ernest Renan (1823–1892)