Anadarko may refer to:
- Anadarko, Oklahoma
- Anadarko Basin, a geologic depositional and structural basin centered in the western part of the state of Oklahoma and the Texas Panhandle, and extending into western Kansas and southeast Colorado
- Anadarko tribe, a Caddo tribe from eastern Texas
- Anadarko Petroleum Corporation, one of the world’s largest independent oil and gas exploration and production companies
- Amma Darko (born 1956), African novelist
- Anadarko Daily News, the largest daily paper of Caddo County, Oklahoma
- Anadarko Public Schools
- Anadarko Tower, a skyscraper located in The Woodlands, Texas