Negative
"Negative" acute-phase proteins decrease in inflammation. Examples include albumin, transferrin, transthyretin, retinol-binding protein, antithrombin, transcortin. The decrease of such proteins may be used as markers of inflammation. The physiological role of decreased synthesis of such proteins is generally to save amino acids for producing "positive" acute-phase proteins more efficiently. Theoretically, a decrease in transferrin could additionally be decreased by an upregulation of transferrin receptors, but the latter does not appear to change with inflammation.
Read more about this topic: Acute-phase Protein
Famous quotes containing the word negative:
“A negative judgment gives you more satisfaction than praise, provided it smacks of jealousy.”
—Jean Baudrillard (b. 1929)
“Most literature on the culture of adolescence focuses on peer pressure as a negative force. Warnings about the “wrong crowd” read like tornado alerts in parent manuals. . . . It is a relative term that means different things in different places. In Fort Wayne, for example, the wrong crowd meant hanging out with liberal Democrats. In Connecticut, it meant kids who weren’t planning to get a Ph.D. from Yale.”
—Mary Kay Blakely (20th century)
“The negative cautions of science are never popular. If the experimentalist would not commit himself, the social philosopher, the preacher, and the pedagogue tried the harder to give a short- cut answer.”
—Margaret Mead (1901–1978)