Synthesis
The usual method involves the reaction of acetic acid with standard inorganic chlorodehydrating agents, such as by using PCl3, PCl5, SO2Cl2, or SOCl2. However, this usually gives acetyl chloride which is contaminated by phosphorus or sulfur impurities, which may interfere with the organic reactions.
It is produced by the reaction of hydrogen chloride with acetic anhydride:
- (CH3CO)2O + HCl → CH3COCl + CH3CO2H
HCl impurities can be removed by distilling the crude product from dimethylaniline or by degassing the mixture by a stream of argon.
It may also be synthesized from the catalytic carbonylation of methyl chloride.
Heating dichloroacetic chloride with acetic acid also gives acetyl chloride in 70% yield.
Read more about this topic: Acetyl Chloride
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