Clinical Significance
A deficiency of 1-phosphofructokinase can be inherited due to the genetic disorder glycogenosis type VII Tarui's disease. Research has shown that this disease can lead to insulin resistance and reduced insulin secretion by beta cells in the pancreas, leading to non-insulin-dependent diabetes mellitus, or diabetes type 2. Non-insulin-dependent diabetes mellitus is considered a global epidemic by the World Health Organization.
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“History is the interpretation of the significance that the past has for us.”
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