Research
Kan is regarded as a pioneer of applying molecular biology and genetics into clinical medicine. Kan was the first to establish that a single DNA mutation could lead to a human disease, and the first to diagnose a human disease by using DNA.
Kan has made many fundamental contributions to our understanding of human blood diseases. Kan was the first to discover the gene deletion in human alpha-thalassemia; he was the first to discover a point-mutation causing human beta-thalassemia; with Golbus' help, he was the first to carry out prenatal diagnosis (for a haemoglobinopathy).
Kan is best known for his groundbreaking works in sickle cell and thalassemia. He is the first person who used fetal DNA diagnosis techniques to study these diseases. Kan's work led to the innovation of DNA diagnosis.
Kan discovered DNA polymorphism, which nowadays is widely used in genetic analysis for human diseases.
Read more about this topic: Yuet Wai Kan
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