Gene Ontology | |
---|---|
Molecular function | • tRNA binding • tyrosine-tRNA ligase activity • signal transducer activity • interleukin-8 receptor binding • ATP binding |
Cellular component | • extracellular space • nucleus • cytoplasm • cytosol |
Biological process | • tRNA aminoacylation for protein translation • tyrosyl-tRNA aminoacylation • apoptotic process • signal transduction • gene expression |
Sources: Amigo / QuickGO |
33.24 – 33.28 Mb
129.19 – 129.22 Mb
Tyrosyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the YARS gene.
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.