Yang Sen is the name of:
- Yang Sen (1884–1977), Chinese warlord and general
- Yang Sen (1916–2004), Chinese general of the Communist Party of China
- Yang Sen (baseball) (born 1981), Taiwanese baseball player
- Yeung Sum (born 1947), also Yang Sen in pinyin, Hong Kong politician
- Victor Sen Yung (1915–1980), American character actor
- Yang Sen (athlete), Chinese gold medal winner at the 2008 Summer Paralympics
- Sen Yang, Chinese proffesional swimmer, founder of the Richmond Hill Swimming Dragons swim club