Xiap

XIAP

Identifiers Symbols XIAP; API3; BIRC4; IAP-3; ILP1; MIHA; XLP2; hIAP-3; hIAP3 External IDs OMIM: 300079 MGI: 107572 HomoloGene: 901 ChEMBL: 4198 GeneCards: XIAP Gene EC number 6.3.2.-

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • protein binding • zinc ion binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • metal ion binding
Cellular component	• nucleus • cytoplasm • cytosol
Biological process	• apoptotic process • response to DNA damage stimulus • Wnt receptor signaling pathway • regulation of BMP signaling pathway • regulation of cell proliferation • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of innate immune response • regulation of inflammatory response • copper ion homeostasis • regulation of nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of canonical Wnt receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 331 11798 Ensembl ENSG00000101966 ENSMUSG00000025860 UniProt P98170 Q60989 RefSeq (mRNA) NM_001167.3 NM_009688.2 RefSeq (protein) NP_001158.2 NP_033818.2 Location (UCSC) Chr X:
122.99 – 123.05 Mb Chr X:
42.06 – 42.11 Mb PubMed search

X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC), is a protein that stops apoptotic cell death. In human, this protein (XIAP) is produced by a gene named XIAP gene located on the X chromosome.