XIAP

XIAP

Identifiers Symbols XIAP; API3; BIRC4; IAP-3; ILP1; MIHA; XLP2; hIAP-3; hIAP3 External IDs OMIM: 300079 MGI: 107572 HomoloGene: 901 ChEMBL: 4198 GeneCards: XIAP Gene EC number 6.3.2.-

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • protein binding • zinc ion binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • metal ion binding
Cellular component	• nucleus • cytoplasm • cytosol
Biological process	• apoptotic process • response to DNA damage stimulus • Wnt receptor signaling pathway • regulation of BMP signaling pathway • regulation of cell proliferation • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of innate immune response • regulation of inflammatory response • copper ion homeostasis • regulation of nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of canonical Wnt receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 331 11798 Ensembl ENSG00000101966 ENSMUSG00000025860 UniProt P98170 Q60989 RefSeq (mRNA) NM_001167.3 NM_009688.2 RefSeq (protein) NP_001158.2 NP_033818.2 Location (UCSC) Chr X:
122.99 – 123.05 Mb Chr X:
42.06 – 42.11 Mb PubMed search

X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC), is a protein that stops apoptotic cell death. In human, this protein (XIAP) is produced by a gene named XIAP gene located on the X chromosome.

XIAP is a member of the inhibitor of apoptosis family of proteins (IAP). IAPs were initially identified in baculoviruses, but XIAP is one of the homologous proteins found in mammals. It is so called because it was first discovered by a 273 base pair site on the X chromosome. The protein is also called human IAP-like Protein (hILP), because it is not as well conserved as the human IAPS: hIAP-1 and hIAP-2. XIAP is the most potent human IAP protein currently identified.