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- Xanthus, the Latin form of Xanthos, an ancient Lycian city
- 4544 Xanthus (1989 FB) is an Apollo NEO discovered on March 31, 1989 by Henry Holt and Norman G. Thomas at Palomar Observatory
- Xanthus class repair ship, class of five auxiliary ships built for the United States Navy and Royal Navy
- USS Xanthus (AR-19), a Xanthus-class repair ship acquired by the United States Navy for the task of providing repairs to the fleet
- Xanthus stele or Xanthian Obelisk, a stele bearing an inscription currently believed to be trilingual, in the ancient Lycian city of Xanthos
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