Sportsmen
- William H. Lewis (1868–1949), first African-American All-American football player and United States Assistant Attorney General
- William Lewis (athlete) (1876–1962), American hurdler in the 1900 Olympic Games
- William Ian Lewis (cricketer) (1935–2004), Irish cricketer
- William Lewis (figure skater), former Canadian figure skater
- William Lewis (football) (fl. 1900), association football referee, and secretary of Chelsea F.C.
- William Lewis (chess player) (1787–1870), English chess player and author
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