Role in Cancer
The mitosis promoting factor MPF also regulates DNA-damage induced apoptosis. Negative regulation of MPF by WEE1 causes aberrant mitosis and thus resistance to DNA-damage induced apoptosis. Kruppel-like factor 2 (KLF2) negatively regulates human WEE1, thus increasing sensitivity to DNA-damage induced apoptosis in cancer cells.
Read more about this topic: Wee1
Famous quotes containing the words role and/or cancer:
“Is not our role to stand for the one thing which means our own salvation here but with which it will also be possible to save the world, and with which Europe will be able to save itself, namely the preservation of the white man and his state?”
—Hendrik Verwoerd (19011966)
“The same people who tell us that smoking doesnt cause cancer are now telling us that advertising cigarettes doesnt cause smoking.”
—Ellen Goodman (b. 1941)