USS Gloucester (PF-22), a Tacoma-class frigate, was the second ship of the United States Navy to be named for Gloucester, Massachusetts.
The second Gloucester (PF-22), originally classified PG-130, was launched on 12 July 1943 at the Walter Butler Shipbuilding Company in Superior, Wisconsin, under a Maritime Commission contract, sponsored by Mrs. Emily K. Ross; acquired and simultaneously commissioned on 10 December 1943.