Regulation
UMPS is subject to complex regulation by OMP, the product of its OPRTase and the substrate for the ODCase. OMP is an allosteric activator of OMP decarboxylase activity. At low enzyme concentration and low OMP concentrations, OMP decarboxylase shows negative cooperativity, while at higher OMP concentrations, the enzyme shows positive cooperativity. However, when enzyme concentrations are higher, these complex kinetics do not manifest. Orotate PRTase activity is activated by low concentrations of OMP, phosphate, and ADP.
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