Uricosuric - Secondary Uricosurics

Secondary Uricosurics

Drugs with other primary uses, that have known uricosuric properties, include guaifenesin, losartan, atorvastatin, and fenofibrate. Although these drugs may have significant uricosuric action, their other significant pharmacological actions in off-label use as a uricosuric requires careful assessment of the patient to achieve the most benefit and least risk.

  • Amlodipine
  • Atorvastatin (lowers cholesterol)
  • Fenofibrate (lowers triglycerides, raises HDL)
  • Guaifenesin (expectorant)
  • Losartan
  • Adrenocorticotropic hormone
  • Cortisone

Abdominal surgery also has a uricosuric effect, as well as the potential to precipitate an acute attack of gout.

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