Secondary Uricosurics
Drugs with other primary uses, that have known uricosuric properties, include guaifenesin, losartan, atorvastatin, and fenofibrate. Although these drugs may have significant uricosuric action, their other significant pharmacological actions in off-label use as a uricosuric requires careful assessment of the patient to achieve the most benefit and least risk.
- Amlodipine
- Atorvastatin (lowers cholesterol)
- Fenofibrate (lowers triglycerides, raises HDL)
- Guaifenesin (expectorant)
- Losartan
- Adrenocorticotropic hormone
- Cortisone
Abdominal surgery also has a uricosuric effect, as well as the potential to precipitate an acute attack of gout.
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“A man may be defeated by his own secondary successes.”
—Woodrow Wilson (18561924)