U2 Small Nuclear RNA Auxiliary Factor 1

U2 Small Nuclear RNA Auxiliary Factor 1

Identifiers Symbols U2AF1; FP793; RN; RNU2AF1; U2AF35; U2AFBP External IDs OMIM: 191317 MGI: 98884 HomoloGene: 14345 GeneCards: U2AF1 Gene

Gene Ontology
Molecular function • nucleotide binding
• RNA binding
• protein binding
• zinc ion binding
• RS domain binding
Cellular component • nucleus
• nucleoplasm
• spliceosomal complex
• nucleolus
• Cajal body
• nuclear speck
• catalytic step 2 spliceosome
Biological process • mRNA splicing, via spliceosome
• transcription from RNA polymerase II promoter
• termination of RNA polymerase II transcription
• mRNA processing
• mRNA export from nucleus
• RNA splicing
• gene expression
• mRNA 3'-end processing
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7307 108121 Ensembl ENSG00000160201 ENSMUSG00000061613 UniProt Q01081 Q9D883 RefSeq (mRNA) NM_001025203 NM_001163769 RefSeq (protein) NP_001020374 NP_001157241 Location (UCSC) Chr 21:
44.51 – 44.53 Mb Chr 17:
31.65 – 31.66 Mb PubMed search

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.

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