Symptoms
Because the vast majority of Triple X females are never diagnosed, it may be very difficult to make generalizations about the effects of this syndrome. The samples that were studied were small and may be non-representative or biased.
Because of the lyonization, inactivation, and formation of a Barr body in all female cells, only one X chromosome is active at any time. Thus, Triple X syndrome most often has only mild effects, or has no unusual effects at all. Symptoms may include tall stature; small head (microcephaly); vertical skinfolds that may cover the inner corners of the eyes (epicanthal folds); delayed development of certain motor skills, speech and language; learning disabilities, such as dyslexia; or weak muscle tone. The symptoms vary from person to person, with some women being more affected than others. There are seldom any observable physical anomalies in Triple X females, other than being taller than average.
Girls with Triple X syndrome are at increased risk of delayed language development, EEG abnormalities, motor-coordination problems and auditory-processing disorders, and scoliosis. They tend to show accelerated growth until puberty. Premature ovarian failure seems to be more prevalent in these women, but most Triple X women seem to have normal fertility. Triple X females are more likely to struggle with personality and psychological problems, and low self-esteem, but these respond well to treatment. Triple X girls are at increased risk of poor academic results at school, and some may need special education. Sometimes, they may suffer from anxiety and be very shy, and this may affect their relations with school peers. They seem to feel much better after leaving school. They benefit very much from a stable home environment. However, much more research is needed to fully understand the effects of this condition.
Read more about this topic: Triple X Syndrome
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