Tripartite Motif Family - Family Members

Family Members

The TRIM family is split into two groups that differ in domain structure and genomic organization:

  • Group 1 members possess a variety of C-terminal domains, and are represented in both vertebrate and invertebrates
  • Group 2 is absent in invertebrates, possess a C-terminal SPRY domain

Members of the family include:

  • Group 1
    • PHD-BROMO domain containing: TRIM24 (TIF1α), TRIM28 (TIF1β), TRIM33 (TIF1γ)– act as corepressors
    • 1-10: TRIM1, TRIM2, TRIM3, TRIM8, TRIM9
    • 11-20: TRIM12, TRIM13, TRIM14, TRIM16, TRIM18, TRIM19
    • 21-30: TRIM23, TRIM25, TRIM29, TRIM30
    • 31-40: TRIM32, TRIM36, TRIM37
    • 41-50: TRIM42, TRIM44, TRIM45, TRIM46, TRIM47
    • 51-60: TRIM51, TRIM53, TRIM54, TRIM55, TRIM56, TRIM57, TRIM59
    • 61-70: TRIM62, TRIM63, TRIM65, TRIM66, TRIM67, TRIM69, TRIM70
    • 71-75: TRIM71
  • Group 2
    • 1-10: TRIM4, TRIM5, TRIM6, TRIM7, TRIM10
    • 11-20: TRIM11, TRIM12, TRIM15, TRIM17, TRIM20
    • 21-30: TRIM21, TRIM22, TRIM26, TRIM27, TRIM30
    • 31-40: TRIM31, TRIM34, TRIM35, TRIM38, TRIM39, TRIM40
    • 41-50: TRIM41, TRIM43, TRIM48, TRIM49, TRIM50
    • 51-60: TRIM51, TRIM52, TRIM53, TRIM57, TRIM58, TRIM60
    • 61-70: TRIM61, TRIM64, TRIM68, TRIM69, TRIM70
    • 71-75: TRIM72, TRIM73, TRIM74, TRIM75

Read more about this topic:  Tripartite Motif Family

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