TRIM33

TRIM33

Identifiers Symbols TRIM33; ECTO; PTC7; RFG7; TF1G; TIF1G; TIF1GAMMA; TIFGAMMA External IDs OMIM: 605769 MGI: 2137357 HomoloGene: 9296 GeneCards: TRIM33 Gene

Gene Ontology
Molecular function	• DNA binding • ubiquitin-protein ligase activity • protein binding • zinc ion binding • co-SMAD binding • R-SMAD binding
Cellular component	• nucleus • nucleoplasm • nucleolus • intracellular membrane-bounded organelle
Biological process	• negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • transforming growth factor beta receptor signaling pathway • gene expression • protein ubiquitination • regulation of transforming growth factor beta receptor signaling pathway • negative regulation of BMP signaling pathway • negative regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 51592 94093 Ensembl ENSG00000197323 ENSMUSG00000033014 UniProt Q9UPN9 Q99PP7 RefSeq (mRNA) NM_015906 NM_001079830 RefSeq (protein) NP_056990 NP_001073299 Location (UCSC) Chr 1:
114.94 – 115.05 Mb Chr 3:
103.28 – 103.36 Mb PubMed search

Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ), is a human gene.

The protein encoded by this gene is thought to be a transcriptional corepressor. However unlike the related TIF1-α and TIF1-β proteins, few transcription factors such as Smad4 that interact with TIF1-γ have been identified.