TRIM21

TRIM21

Identifiers Symbols TRIM21; RNF81; RO52; SSA; SSA1 External IDs OMIM: 109092 MGI: 106657 HomoloGene: 2365 GeneCards: TRIM21 Gene EC number 6.3.2.-

Gene Ontology
Molecular function	• DNA binding • RNA binding • ubiquitin-protein ligase activity • protein binding • zinc ion binding
Cellular component	• cytoplasmic mRNA processing body • nucleus • nucleolus • cytoplasm • SCF ubiquitin ligase complex • ribonucleoprotein complex
Biological process	• protein polyubiquitination • protein monoubiquitination • cell cycle • protein ubiquitination • protein destabilization • negative regulation of NF-kappaB transcription factor activity • positive regulation of cell cycle • protein autoubiquitination • protein trimerization • negative regulation of protein deubiquitination
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6737 20821 Ensembl ENSG00000132109 ENSMUSG00000030966 UniProt P19474 Q62191 RefSeq (mRNA) NM_003141 NM_001082552 RefSeq (protein) NP_003132 NP_001076021 Location (UCSC) Chr 11:
4.41 – 4.41 Mb Chr 7:
102.56 – 102.57 Mb PubMed search

Tripartite motif-containing protein 21 also known as E3 ubiquitin-protein ligase TRIM21 is a protein that in humans is encoded by the TRIM21 gene. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. It is expressed in most human tissues.