Rejection Detection
Diagnosis of acute rejection relies on clinical data—patient signs and symptoms—but also calls on laboratory data such as tissue biopsy. The laboratory pathologist generally seeks three main histological signs: (1) infiltrating T cells, perhaps accompanied by infiltrating eosinophils, plasma cells, and neutrophils, particularly in telltale ratios, (2) structural compromise of tissue anatomy, varying by tissue type transplanted, and (3) injury to blood vessels. Tissue biopsy is restricted, however, by sampling limitations and risks/complications of the invasive procedure. Cellular magnetic resonance imaging (MRI) of immune cells radiolabeled in vivo might offer noninvasive testing.
Read more about this topic: Transplant Rejection
Famous quotes containing the word rejection:
“Oh, the holiness of always being the injured party. The historically oppressed can find not only sanctity but safety in the state of victimization. When access to a better life has been denied often enough, and successfully enough, one can use the rejection as an excuse to cease all efforts. After all, one reckons, “they” don’t want me, “they” accept their own mediocrity and refuse my best, “they” don’t deserve me.”
—Maya Angelou (b. 1928)