In enzymology, a trans-cinnamate 4-monooxygenase (EC 1.14.13.11) is an enzyme that catalyzes the chemical reaction
- trans-cinnamate + NADPH + H+ + O2 4-hydroxycinnamate + NADP+ + H2O
The 4 substrates of this enzyme are trans-cinnamate, NADPH, H+, and O2, whereas its 3 products are 4-hydroxycinnamate, NADP+, and H2O. This enzyme participates in phenylalanine metabolism and phenylpropanoid biosynthesis. It employs one cofactor, heme.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor.
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