Computing
- Tape Operating System, predecessor to IBM's Disk Operating System
- Atari TOS, the operating system of the Atari ST computers
- TinyOS, an open-source operating system designed for wireless embedded sensor networks
- Talend Open Studio, an open source ETL tool
- TOSLINK, a standardized optical fibre connection system
- Type of Service, policy-based routing
- Terminal Operating System, Enterprise software that manages all aspects of a marine port terminal operation
- Top Octave Synthesizer, an integrated circuit used in analog electronic keyboards to generate the tones of a musical scale
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