The Tokugawa Yoshinobu House (徳川慶喜家, Tokugawa Yoshinobu-ke?) was founded in 1902 when Emperor Meiji permitted Tokugawa Yoshinobu, the last Shōgun of Japan, to found a house with the highest rank of nobility, kōshaku (Prince). The title was officially declared obsolete in 1947, though the family still maintains it.
The wife of Prince Takamatsu-no-miya Nobuhito (third son of Emperor Taishō) was Tokugawa Kikuko, daughter of the 2nd Prince of the Yoshinobu-ke, Yoshihisa.
Read more about Tokugawa Yoshinobu-ke: Heads of The Family