Entertainment
- TLC (group), an American R&B/hip hop girl group
- "T.L.C.", a song by the Scottish funk and R&B band Average White Band on their debut album Show Your Hand
- TLC (TV channel), formerly the The Learning Channel, an American cable TV network
- TLC (Asia), an Asian television channel
- TLC Australia & New Zealand, the Australian and New Zealand TV channel Travel and Living Channel
- TLC India, an Indian television channel
- TLC (Latin America)
- TLC (Netherlands), a Dutch television channel, unrelated to The Learning Channel, which broadcasts lifestyle programs
- TLC (Poland), a Polish television channel
- TLC (UK and Ireland), a UK and Ireland television channel
- TLC (TV series), a British situation comedy airing on BBC2
- Tables, Ladders, and Chairs match, a type of professional wrestling match
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- WWE TLC: Tables, Ladders & Chairs, a professional wrestling event based around the above match
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