Voice Cast
- Matt Damon as Cale Tucker, a 20-year-old human with a very large chip on his shoulder who is separated from his father moments before the destruction of Earth by the Drej 15 years earlier. He helps Korso finding the Titan. Animation supervised by Len Simon.
- Alex D. Linz plays Cale at age 5.
- Drew Barrymore as Akima Kunimoto, the pilot of the Valkyrie. She works under Korso and is determined to save the human race from extinction. Animation supervised by Len Simon.
- Bill Pullman as Joseph Korso, the captain of the Valkyrie and once an ally of Sam Tucker. He has Cale join the Valkyrie crew in search of the Titan, but he actually has a very different agenda. Animation supervised by Len Simon.
- Christopher Scarabosio as Drej Queen, the leader of the Drej who believes that humanity is a threat to the Drej, and tries to purge them from the universe.
- John Leguizamo as Gune, Grepoan and Korso's eccentric scientist. While he behaves in a very odd fashion, he is extremely intelligent: in addition to astrogation and science, he knows how to pilot the Valkyrie and fire its weapons, but he had a serious distraction problem. Animation supervised by Troy Saliba.
- Nathan Lane as Preedex Yoa, Korso's first mate. An Akrennian (a race of bat-like creatures) who speaks with an English accent, Preed is sarcastic with the crew. Having cared about his own life, he allies with the Drej and betrays the crew by attempting to leave them for dead, but is killed by Korso, who breaks his neck in revenge. "The particular alien race that Preed belongs to is very haughty, floating above it all," explains co-director Goldman. "Nathan just seemed appropriate--he can really put on airs when he needs to." In giving voice to Preed, Lane has said he took aural inspiration from none other than the imperious George Sanders. Described in the Ben Edlund 12/15/97 Goldenrod Production draft of the screenplay as a "fruit bat-faced alien". Animation supervised by Edison Goncalves.
- Janeane Garofalo as Stith, a kangaroo-like alien known as a Mantrin/Sogowan, who has a cranky but lovable attitude. She is Korso's tough weapons expert, a friend of Akima and likes Gune, not Preed. Animation supervised by Troy Saliba.
- Ron Perlman as Sam Tucker, Cale's father who saves his son from the Drej and was presumably killed because he refused to disclose the Titan's location to them.
- Tone Loc as Tek, a university student and Sam Tucker's friend. Fifteen years later, he apparently became totally blind though it never mentioned in the film, but hinted when he struggles to find a salt shaker on his table. Animation supervised by Edison Goncalves.
- Jim Breuer as The Cook, a cockroach-like alien who despises humans. The Ben Edlund 12/15/97 Goldenrod Production draft of the screenplay reveals his name as It, though no mention is this is ever made in the film. When the Drej come looking for Cale and Korso, the Cook tells them which direction they fled, and the Drej repay him by shooting him dead.
- Jim Cummings as Chowquin, Cale's overseer at Tau 14. He is openly biased against humans and refuses to allow Cale into the cafeteria with the other aliens, prompting him to go round the back.
- Charles Rocket as Firrikash, Cale's alien co-worker at Tau-14, who despises humans. He, along with his friend, Po, tries to beat Cale up at the basement of the space station, but Korso stops and subdues them both.
- Ken Hudson Campbell as Po, Cale's other alien co-worker.
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