Side Effects
Tianeptine was both studied for short-term (3 month) and long-term treatment (12 months) and equally well tolerated. The studies encompassed 1,300 to nearly 3,000 patients each.
Side effects are as follows (amitriptyline vs tianeptine):
- Dry mouth (38% vs 20%)
- Constipation (19% vs 15%)
- Dizziness/syncope (23% vs 13%)
- Drowsiness (17% vs 10%)
- Postural hypotension (8% vs 3%)
- Insomnia and vivid dreams (7% vs 20%)
Costa e Silva and colleagues at the Jardim Botanico in Rio de Janeiro, Brazil reported a greater frequency of headaches in the tianeptine group as compared with placebo.
Sema Gülen Yıldırım and colleagues reported in 2004 of a case of hypomania caused by tianeptine.
Interestingly, tianeptine along with its two metabolites (S8849, S3139) does not affect the reuptake of monoamines (DA, 5-HT, and noradrenaline) in vitro. Results from in vivo studies confirm that serotonin reuptake is enhanced — while dopamine and noradrenaline are unaffected — suggesting a mechanism independent of SERT. No data is available regarding effects of the drug on postsynaptic receptors.
Read more about this topic: Tianeptine
Famous quotes containing the words side and/or effects:
“I had an old axe which nobody claimed, with which by spells in winter days, on the sunny side of the house, I played about the stumps which I had got out of my bean-field. As my driver prophesied when I was plowing, they warmed me twice,—once while I was splitting them, and again when they were on the fire, so that no fuel could give out more heat. As for the axe,... if it was dull, it was at least hung true.”
—Henry David Thoreau (1817–1862)
“Let us learn to live coarsely, dress plainly, and lie hard. The least habit of dominion over the palate has certain good effects not easily estimated.”
—Ralph Waldo Emerson (1803–1882)