Clinical Significance
As an anti-cancer chemotherapy target, thymidylate synthetase can be inhibited by the thymidylate synthase inhibitors such as fluorinated pyrimidine fluorouracil, or certain folate analogues, the most notable one being raltitrexed (trade name Tomudex).
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“To grasp the full significance of life is the actors duty, to interpret it is his problem, and to express it his dedication.”
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