Thymidylate Synthase

Thymidylate Synthase

Identifiers Symbols TYMS; HST422; TMS; TS External IDs OMIM: 188350 MGI: 98878 HomoloGene: 834 ChEMBL: 1952 GeneCards: TYMS Gene EC number 2.1.1.45

Gene Ontology
Molecular function	• nucleotide binding • mRNA binding • thymidylate synthase activity • folic acid binding • drug binding • protein homodimerization activity • cofactor binding
Cellular component	• nucleus • nucleoplasm • nucleolus • cytoplasm • mitochondrion • mitochondrial inner membrane • mitochondrial matrix • cytosol
Biological process	• G1/S transition of mitotic cell cycle • regulation of transcription involved in G1/S phase of mitotic cell cycle • mitotic cell cycle • polysaccharide metabolic process • nucleobase-containing compound metabolic process • pyrimidine nucleobase metabolic process • dTMP biosynthetic process • dTTP biosynthetic process • DNA replication • DNA repair • aging • circadian rhythm • deoxyribonucleoside monophosphate biosynthetic process • response to toxic substance • immortalization of host cell by virus • uracil metabolic process • organ regeneration • response to progesterone stimulus • response to vitamin A • response to cytokine stimulus • response to drug • small molecule metabolic process • response to ethanol • dUMP metabolic process • pyrimidine nucleoside biosynthetic process • tetrahydrofolate metabolic process • response to organophosphorus • phosphatidylinositol-mediated signaling • developmental growth • cartilage development • response to glucocorticoid stimulus • response to folic acid • nucleobase-containing small molecule metabolic process • intestinal epithelial cell maturation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7298 22171 Ensembl ENSG00000176890 ENSMUSG00000025747 UniProt P04818 P07607 RefSeq (mRNA) NM_001071 NM_021288 RefSeq (protein) NP_001062 NP_067263 Location (UCSC) Chr 18:
0.66 – 0.67 Mb Chr 5:
30.06 – 30.07 Mb PubMed search

thymidylate synthase

Identifiers

EC number

2.1.1.45

CAS number

9031-61-2

Databases

IntEnz

IntEnz view

BRENDA

BRENDA entry

ExPASy

NiceZyme view

KEGG

KEGG entry

MetaCyc

metabolic pathway

PRIAM

profile

PDB structures

Gene Ontology

Search
PMC	articles
PubMed	articles
NCBI	proteins

Thymidylate synthase

Identifiers

Symbol

Thymidylat_synt

Pfam

PF00303

InterPro

IPR000398

PROSITE

PDOC00086

SCOP

1tys

SUPERFAMILY

1tys

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

Thymidylate synthetase (EC 2.1.1.45) is the enzyme used to generate thymidine monophosphate (dTMP), which is subsequently phosphorylated to thymidine triphosphate for use in DNA synthesis and repair.

Read more about Thymidylate Synthase: Function, Clinical Significance, Interactive Pathway Map