Thymidine Kinase 1

Thymidine Kinase 1

Identifiers Symbols TK1; TK2 External IDs OMIM: 188300 MGI: 98763 HomoloGene: 37749 ChEMBL: 2883 GeneCards: TK1 Gene EC number 2.7.1.21

Gene Ontology
Molecular function	• thymidine kinase activity • ATP binding • zinc ion binding • nucleoside kinase activity
Cellular component	• cytosol
Biological process	• liver development • nucleobase-containing compound metabolic process • pyrimidine nucleobase metabolic process • DNA replication • nucleotide biosynthetic process • response to toxic substance • skeletal muscle cell proliferation • response to nutrient levels • pyrimidine nucleoside salvage • small molecule metabolic process • thymidine metabolic process • response to copper ion • digestive tract development • protein homotetramerization • response to cortisol stimulus • nucleobase-containing small molecule metabolic process • fetal process involved in parturition
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7083 21877 Ensembl ENSG00000167900 ENSMUSG00000025574 UniProt P04183 P04184 RefSeq (mRNA) NM_003258 NM_001271729 RefSeq (protein) NP_003249 NP_001258658 Location (UCSC) Chr 17:
76.17 – 76.18 Mb Chr 11:
117.82 – 117.83 Mb PubMed search

Thymidine kinase 1, soluble (gene name TK1), is a human thymidine kinase.

Two forms of this protein have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.