Thiocyanate - Biological Chemistry of Thiocyanate in Medicine

Biological Chemistry of Thiocyanate in Medicine

Thiocyanate is known to be an important part in the biosynthesis of hypothiocyanite by a lactoperoxidase. Thus the complete absence of thiocyanate or reducted thiocyanate in the human body, (e.g., cystic fibrosis) is damaging to the human host defense system. Thiocyanate is a potent competitive inhibitor of the thyroid sodium-iodide symporter.

Thiocyanate is a metabolite of sodium nitroprusside, after rhodanese catalyses its reaction with thiosulfate.

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