History
- 1989: Tg-rasH2 mice were first developed in CIEA.
- 1992: CIEA started development of carcinogenicity bioassay system using Tg-rasH2 mice.
- 1996: Policy to replace the 2-year study on mice with the short-term study decided at ICH4.
- 1996-2000: Usefulness of rasH2 mice validated by ILSI/HESI international research.
- 2001: Production and sales of Tg-rasH2 mice.
Read more about this topic: Tg-ras H2 Mouse
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