Computers
- tc (command), a command-line utility used to configure network traffic control in the Linux kernel
- tc, Internet shorthand for "take care"
- .tc, the Internet country code top-level domain (ccTLD) for Turks and Caicos Islands
- Telecine (copying), a form of digital transfer using a Telecine machine
- Total Commander, an Orthodox File Manager software
- TrueCrypt, a disk encryption software
- Trusted Computing, a scheme for adding additional controls on what computers may or may not do into hardware or software
- Turbo C, a software development program by Borland
- Test Case, a concept in software engineering
- TRON Code, a multi-byte character encoding used in the TRON Project
- Thin client, a computer or computer program that is heavily dependent on another computer (server) to operate
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