| Gene Ontology | |
|---|---|
| Molecular function | • RNA polymerase II transcription factor binding • RNA polymerase II activating transcription factor binding • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding |
| Cellular component | • nucleus |
| Biological process | • negative regulation of transcription from RNA polymerase II promoter • skeletal system development • blood vessel development • in utero embryonic development • heart looping • outflow tract morphogenesis • atrioventricular bundle cell differentiation • transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • cell aging • positive regulation of cell proliferation • anterior/posterior axis specification, embryo • organ morphogenesis • specification of organ position • stem cell maintenance • limbic system development • male genitalia development • female genitalia development • negative regulation of epithelial cell differentiation • mammary gland development • luteinizing hormone secretion • embryonic forelimb morphogenesis • forelimb morphogenesis • embryonic digit morphogenesis • negative regulation of apoptotic process • negative regulation of myoblast differentiation • positive regulation of cell cycle • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • follicle-stimulating hormone secretion • mesoderm morphogenesis • palate development • ventricular septum morphogenesis • branching involved in mammary gland duct morphogenesis • mammary placode formation • cardiac muscle cell fate commitment • sinoatrial node cell development • cellular senescence • positive regulation of stem cell proliferation |
| Sources: Amigo / QuickGO | |
115.11 – 115.12 Mb
119.67 – 119.68 Mb
T-box transcription factor TBX3 is a protein that in humans is encoded by the TBX3 gene.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. Mutations in TBX3 are implicated in cases of breast cancer.