| Gene Ontology | |
|---|---|
| Molecular function | • DNA binding • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding |
| Cellular component | • nucleus • transcription factor complex |
| Biological process | • negative regulation of transcription from RNA polymerase II promoter • outflow tract septum morphogenesis • outflow tract morphogenesis • endocardial cushion morphogenesis • regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation • transcription, DNA-dependent • muscle cell fate determination • cell aging • positive regulation of cell proliferation • aorta morphogenesis • atrioventricular canal development • embryonic digit morphogenesis • negative regulation of transcription, DNA-dependent • embryonic camera-type eye morphogenesis • cardiac muscle tissue development • palate development • positive regulation of cardiac muscle cell proliferation • pharynx development • developmental growth involved in morphogenesis • mammary placode formation • cellular senescence • negative regulation of heart looping • negative regulation of cardiac chamber formation |
| Sources: Amigo / QuickGO | |
59.48 – 59.49 Mb
85.83 – 85.84 Mb
T-box transcription factor TBX2 is a protein that in humans is encoded by the TBX2 gene.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.
In melanocytic cell types, expression of the T-box 2 gene is regulated by the Microphthalmia-associated transcription factor.