SPOP

SPOP

Identifiers Symbols SPOP; BTBD32; TEF2 External IDs OMIM: 602650 MGI: 1343085 HomoloGene: 68354 GeneCards: SPOP Gene

Gene Ontology
Molecular function	• protein binding • ubiquitin protein ligase binding
Cellular component	• nucleus • nuclear speck • Cul3-RING ubiquitin ligase complex
Biological process	• protein ubiquitination • proteasomal ubiquitin-dependent protein catabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8405 20747 Ensembl ENSG00000121067 ENSMUSG00000057522 UniProt O43791 Q6ZWS8 RefSeq (mRNA) NM_001007226 NM_025287 RefSeq (protein) NP_001007227 NP_079563 Location (UCSC) Chr 17:
47.68 – 47.76 Mb Chr 11:
95.41 – 95.49 Mb PubMed search

Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.