Miscellaneous
- SPO, aka Matthew A. Spolar
- SPO:), a Lithuanian sports magazine
- SPO Rouen Basket, a basketball club in Rouen, France
- Scholarly Publishing Office of the University of Michigan University Library
- Serbian Renewal Movement a monarchist political party
- Socialist Party of Ontario a minor political party in the Canadian Province of Ontario
- Service and Parts Operations, in the automotive industry
- Strengthening Participatory Organization, a rights-based organization in Pakistan
- System Program Office, in the U.S. Department of Defense
- .spo, a file extension used in the SPSS statistics software
- Supreme Prosecutors' Office of the Republic of Korea is a South Korean prosecutor organization
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