Entertainment
- The Spine, a 2004 They Might Be Giants album, including the songs "Spine" and "Spines"
- The Spine (film), a 2009 animated short by Chris Landreth
- Spinal (Killer Instinct), a fictional character from the video game Killer Instinct
- Spinal Tap (band), a semi-fictional heavy metal band
- Spine, a demon in Blood Beast, 2007 book of the Demonata saga
- the Spine, the mountain chain which follows the west coast in the Inheritance cycle.
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