Sperl can refer to:
- Andreas Sperl (born ?), CFO of aircraft manufacturer Airbus
- Antje Vogel-Sperl (born 1956, Bayreuth), German female politician (Bündnis 90/Die Grünen)
- August Sperl (1862–1926), German writer and archivist
- Daniel Šperl (born 1966, Tábor), Czech photographer, cameraman, and historian
- Gerfried Sperl (born 1941, Oberzeiring), Austrian journalist
- Hans Sperl (1861–1959), Austrian writer and jurist
- Harald "Lumpi" Spörl (born 1966, Bamberg), German football player
- Jaroslav Šperl
- Johann Sperl (Spörl) (1840, Buch, nearby Fürth - 1914), German painter
- Ludwik Szperl, Polish chemist
- Milan Šperl (1980, Karlovy Vary), Czech cross-country skier
- Natalie Denise Sperl (1979, New Ulm, Minnesota), Austrian-American model and actress
- Robert Zeppel-Sperl (1944, Leoben - 2005), Austrian painter
- Sonja Sperl (born 1936, Bayerisch Eisenstein), Austrian skier
- Timothy Sperl (1922–1989), an American film actor