Sonogashira Coupling

Sonogashira Coupling

The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon–carbon bonds. It makes use of a palladium catalyst to form a carbon–carbon bond between a terminal alkyne and an aryl or vinyl halide.

The Sonogashira cross-coupling reaction has been employed in a wide variety of areas, due to its usefulness in the formation of carbon–carbon bonds. The reaction can be carried out under mild conditions, such as at room temperature, in aqueous media, and with a mild base, which has allowed for the use of the Sonogashira cross-coupling reaction in the synthesis of complex molecules. Its applications include pharmaceuticals, natural products, organic materials, and nanomaterials. Specific examples include its use in the synthesis of tazarotene, which is a treatment for psoriasis and acne, and in the preparation of SIB-1508Y, also known as Altinicline, which is a potential treatment for Parkinson's disease, Alzheimer's disease, Tourette syndrome, schizophrenia, and attention deficit hyperactivity disorder (ADHD).