SOD3

Identifiers Symbols SOD3; EC-SOD External IDs OMIM: 185490 MGI: 103181 HomoloGene: 2334 GeneCards: SOD3 Gene EC number 1.15.1.1

Gene Ontology
Molecular function	• superoxide dismutase activity • copper ion binding • protein binding • heparin binding • zinc ion binding
Cellular component	• extracellular space • nucleus • mitochondrion • trans-Golgi network • cytosol • extracellular matrix
Biological process	• response to hypoxia • removal of superoxide radicals • response to copper ion
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6649 20657 Ensembl ENSG00000109610 ENSMUSG00000072941 UniProt P08294 O09164 RefSeq (mRNA) NM_003102 NM_011435 RefSeq (protein) NP_003093 NP_035565 Location (UCSC) Chr 4:
24.79 – 24.8 Mb Chr 5:
52.36 – 52.37 Mb PubMed search

Extracellular superoxide dismutase is an enzyme that in humans is encoded by the SOD3 gene.

This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.