SOD1

SOD1

Identifiers Symbols SOD1; ALS; ALS1; IPOA; SOD; hSod1; homodimer External IDs OMIM: 147450 MGI: 98351 HomoloGene: 392 ChEMBL: 2354 GeneCards: SOD1 Gene EC number 1.15.1.1

Gene Ontology
Molecular function	• superoxide dismutase activity • copper ion binding • protein binding • zinc ion binding • protein phosphatase 2B binding • protein homodimerization activity • chaperone binding
Cellular component	• extracellular region • extracellular space • nucleus • nucleolus • cytoplasm • mitochondrion • mitochondrial matrix • peroxisome • cytosol • plasma membrane • extracellular matrix • cytoplasmic vesicle • dendrite cytoplasm • neuronal cell body • protein complex
Biological process	• activation of MAPK activity • response to superoxide • ovarian follicle development • positive regulation of cytokine production • placenta development • retina homeostasis • response to amphetamine • myeloid cell homeostasis • platelet degranulation • double-strand break repair • apoptotic DNA fragmentation • glutathione metabolic process • superoxide metabolic process • cellular iron ion homeostasis • spermatogenesis • embryo implantation • cell aging • blood coagulation • sensory perception of sound • locomotory behavior • anterograde axon cargo transport • retrograde axon cargo transport • regulation of blood pressure • response to heat • response to organic substance • transmission of nerve impulse • removal of superoxide radicals • platelet activation • response to nutrient levels • peripheral nervous system myelin maintenance • regulation of T cell differentiation in thymus • regulation of multicellular organism growth • response to drug • response to hydrogen peroxide • superoxide anion generation • positive regulation of apoptotic process • positive regulation of catalytic activity • negative regulation of neuron apoptotic process • response to ethanol • negative regulation of cholesterol biosynthetic process • regulation of protein kinase activity • regulation of organ growth • response to copper ion • muscle cell homeostasis • thymus development • response to axon injury • hydrogen peroxide biosynthetic process • regulation of mitochondrial membrane potential • heart contraction • neurofilament cytoskeleton organization • relaxation of vascular smooth muscle • auditory receptor cell stereocilium organization
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6647 20655 Ensembl ENSG00000142168 ENSMUSG00000022982 UniProt P00441 P08228 RefSeq (mRNA) NM_000454 NM_011434 RefSeq (protein) NP_000445 NP_035564 Location (UCSC) Chr 21:
33.03 – 33.04 Mb Chr 16:
90.22 – 90.23 Mb PubMed search

Superoxide dismutase also known as superoxide dismutase 1 or SOD1 is an enzyme that in humans is encoded by the SOD1 gene, located on chromosome 21. SOD1 is one of three human superoxide dismutases.