Skyfire (or variants) can refer to:
- Skyfire (Canberra), an annual fireworks show held in Canberra, Australia
- Skyfire (band), a Swedish metal band
- Skyfire (company), a mobile software company
- Skyfire (web browser)
- Skyfire, the cartoon name for the Transformers character also known as "Jetfire"
- Skyfire, a fictional power in the Grey Griffins novel series
- Skyfire, a trance song released in 2011 by Shogun