Technology
The DNA sequencing is done on a chip that contains many ZMWs. Inside each ZMW, a single active DNA polymerase with a single molecule of single stranded DNA template is immobilized to the bottom through which light can penetrate and create a visualization chamber that allows monitoring of the activity of the DNA polymerase at a single molecule level. The signal from a phospho-linked nucleotide incorporated by the DNA polymerase is detected as the DNA synthesis proceeds which results in the DNA sequencing in real time.
Read more about this topic: Single Molecule Real Time Sequencing
Famous quotes containing the word technology:
“Radio put technology into storytelling and made it sick. TV killed it. Then you were locked into somebody else’s sighting of that story. You no longer had the benefit of making that picture for yourself, using your imagination. Storytelling brings back that humanness that we have lost with TV. You talk to children and they don’t hear you. They are television addicts. Mamas bring them home from the hospital and drag them up in front of the set and the great stare-out begins.”
—Jackie Torrence (b. 1944)
“If we had a reliable way to label our toys good and bad, it would be easy to regulate technology wisely. But we can rarely see far enough ahead to know which road leads to damnation. Whoever concerns himself with big technology, either to push it forward or to stop it, is gambling in human lives.”
—Freeman Dyson (b. 1923)