Sequencing Performance
Pacific Biosciences commercialized SMRT sequencing in 2011, after releasing a beta version of its instrument in late 2010. In April 2013, the company released a new version of the sequencer called the "PacBio RS II" that offered higher throughput and longer sequence reads.
The prototype of the SMRT chip contained ~3000 ZMW holes that allowed parallelized DNA sequencing. In 2012, the SMRT Cells were each patterned with 150,000 ZMW holes that are read in two sets of 75,000.
A new chemistry kit released in 2012 increased the sequencer's read length; an early customer of the chemistry cited mean read lengths of 2.5 to 2.9 kilobases.
Read more about this topic: Single Molecule Real Time Sequencing
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