The Sinclair Method is a treatment for alcoholism that involves the use of opiate antagonists such as naltrexone or nalmefene while continuing normal drinking habits in order to decrease the craving for alcohol over time. It relies upon a mechanism called pharmacological extinction, which works by blocking the positive reinforcement effects of ethanol-triggered endorphin in the brain. Proponents claim that thousands of patients have been cured by the Sinclair Method since the early 1990s.
Read more about Sinclair Method: Treatment, Theory, Evidence of Efficacy, History, Obstacles
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“An involuntary return to the point of departure is, without doubt, the most disturbing of all journeys.”
—Iain Sinclair (b. 1943)
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